3CAI Inhibitor

Solid. Powder

98.00%

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

193.63

DMSO: 250mg/mL (1291.12mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

C10H8ClNO

O=C(CCl)C1=CNC2=CC=CC=C12

28755-03-5

Akt1
Akt2

To examine the antitumor activity of 3CAI in vivo, HCT116 cancer cells are injected into the right flank of individual athymic nude mice. Mice are orally administered 3CAI at 20 or 30mg/kg, I3C at 100mg/kg, or vehicle 5 times a week for 21 days. treatment of mice with 30mg/kg of 3CAI significantly suppresses HCT116 tumor growth by 50% relative to the vehicle-treated group (p<0.05). Remarkably, mice seem to tolerate treatment with these doses of 3CAI without overt signs of toxicity or significant loss of body weight compared with vehicle-treated group. Expression of these AKT-target proteins is strongly suppressed by 30mg/kg of 3CAI in tumor tissues[1].

Cytoskeletal Signaling; Akt; PI3K/Akt/mTOR signaling