A-1165442 Inhibitor

Name: A-1165442 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754451
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754451

A-1165442 is a competitive TRPV1 antagonist. For human TRPV, the IC50 values is 9nM. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

A-1165442, Inhibitor

Full Product Name

A-1165442

Product Gene Name

A-1165442, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

431.86

Solubility

DMSO: 100mg/mL (231.56mM)
H2O: <0.1mg/mL (insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C22H20ClF2N3O2

SMILES

O=C(NC1=CC=CC2=C1C=C(C)N=C2)N[C@H]3C4=CC=C(Cl)C=C4OC(CF)(CF)C3

CAS Number

1221443-94-2

Target & IC50

human TRPV1: ic50 9nM

Product Categories/Family for A-1165442, inhibitor

Membrane transporter/Ion channel; TRP/TRPV Channel

Product References and Citations for A-1165442, inhibitor

Voight EA, et al. Discovery of (R)-1-(7-chloro-2,2-bis(fluoromethyl)chroman-4-yl)-3-(3-methylisoquinolin-5-yl)urea (A-1165442): a temperature-neutral transient receptor potential vanilloid-1 (TRPV1) antagonist with analgesic efficacy. J Med Chem. 2014 Sep 11;57(17):7412-24.
Voight EA, et al. Discovery of (R)-1-(7-chloro-2,2-bis(fluoromethyl)chroman-4-yl)-3-(3-methylisoquinolin-5-yl)urea (A-1165442): a temperature-neutral transient receptor potential vanilloid-1 (TRPV1) antagonist with analgesic efficacy. J Med Chem. 2014 Sep 11;57(17):7412-24.

Other Notes

Small volumes of A-1165442, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for A-1165442 purchase

MBS5754451 is an inhibitor targeting A-1165442.