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ACT-709478 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754476

ACT-709478 is a potent, selective, orally active, and brain penetrating T-type calcium channel blocker. ACT-709478 is used in the research of generalized epilepsies[1]. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ACT-709478, Inhibitor
Full Product Name
ACT-709478
Product Gene Name
ACT-709478, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
425.41
Solubility
DMSO: 125mg/mL (293.83mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C22H18F3N5O
SMILES
O=C(NC1=NN(CC2=NC=C(C#N)C=C2)C=C1)CC3=CC=C(C4(C(F)(F)F)CC4)C=C3
CAS Number
1838651-58-3
Target & IC50
Cav3.1: ic50 6.4nM
Cav3.2: ic50 18nM
Cav3.3: ic50 7.5nM
Cav1.2: ic50 2410nM
In Vitro
ACT-709478 (100, 300mg/kg, p.o., 12 hours) can decreas the cumulative duration of absence-like seizures in mice[1].

Structure of ACT-709478, inhibitor

ACT-709478 Inhibitor – Cat# MBS5754476

Product References and Citations for ACT-709478, inhibitor

Bezena§on O, et al. Discovery of a Potent, Selective T-type Calcium Channel Blocker as a Drug Candidate for the treatment,of Generalized Epilepsies. J Med Chem. 2017 Dec 14;60(23):9769-9789.
Bezena§on O, et al. Discovery of a Potent, Selective T-type Calcium Channel Blocker as a Drug Candidate for the treatment,of Generalized Epilepsies. J Med Chem. 2017 Dec 14;60(23):9769-9789.

Other Notes

Small volumes of ACT-709478, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ACT-709478 purchase

MBS5754476 is an inhibitor targeting ACT-709478.
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