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ALLO-2 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754499

ALLO-2 is a Inhibitor of Drug-Resistant Smo Mutant.It inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6nM. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ALLO-2, Inhibitor
Full Product Name
ALLO-2
Product Gene Name
ALLO-2, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
371.32
Solubility
DMSO: 125mg/mL (336.64mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C18H12F3N5O
SMILES
FC(F)(OC1=CC=C(C=C1)C2=NC(NC3=CC4=C(C=C3)NN=C4)=NC=C2)F
CAS Number
1357350-60-7
Target & IC50
Smo

Structure of ALLO-2, inhibitor

ALLO-2 Inhibitor – Cat# MBS5754499

Product References and Citations for ALLO-2, inhibitor

Tao H, et al. Small molecule antagonists in distinct binding modes inhibit drug-resistant mutant of smoothened. Chem Biol. 2011 Apr 22;18(4):432-7.
Tao H, et al. Small molecule antagonists in distinct binding modes inhibit drug-resistant mutant of smoothened. Chem Biol. 2011 Apr 22;18(4):432-7.

Other Notes

Small volumes of ALLO-2, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ALLO-2 purchase

MBS5754499 is an inhibitor targeting ALLO-2.
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