Olorinab Inhibitor

Name: Olorinab Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754523
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754523

Olorinab (APD 371) is a highly potent, selective and fully efficacious cannabinoid receptor type 2 (CB2) agonist. With an EC50 of 6.2nM for hCB2. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Olorinab, Inhibitor

Full Product Name

Olorinab

Product Synonym Names

APD 371

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

357.41

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C18H23N5O3

SMILES

O=C(C1=NN(C(N=CC=2)=CN2=O)C3=C1C[C@@]4([H])[C@]3([H])C4)N[C@H](CO)C(C)(C)C

CAS Number

1268881-20-4

Target & IC50

hCB2: ic50 6.2nM (EC50)

In Vitro

A comprehensive in vitro profile of Olorinab (APD 371) (6) shows that single digit nanomolar potency and full intrinsic efficacy are maintained in all species assessed. Olorinab (APD 371) is highly selective for CB2 over CB1 in both binding and functional assays. Olorinab (APD 371) induces efficient receptor internalization (~106% relative to the CB1/2 agonist CP55,940) in CHO cells expressing HA-tagged rat CB2 suggesting that, according to the hypothesis, Olorinab (APD 371) would be able to drive agonist-induced receptor recycling[1].

Product Categories/Family for Olorinab, inhibitor

GPCR/G Protein; Cannabinoid Receptor

Product References and Citations for Olorinab, inhibitor

Han S, et al. Discovery of APD371: Identification of a Highly Potent and Selective CB2 Agonist for the treatment,of Chronic Pain. ACS Med Chem Lett. 2017 Nov 30;8(12):1309-1313.
Han S, et al. Discovery of APD371: Identification of a Highly Potent and Selective CB2 Agonist for the treatment,of Chronic Pain. ACS Med Chem Lett. 2017 Nov 30;8(12):1309-1313.

Other Notes

Small volumes of Olorinab, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Olorinab purchase

MBS5754523 is an inhibitor targeting Olorinab.