AR-C155858 Inhibitor

Name: AR-C155858 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754530
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754530

AR-C155858 is an inhibitor of monocarboxylate transporter MCT1 and MCT2 (Kis: 2.3nM and 10nM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

AR-C155858, Inhibitor

Full Product Name

AR-C155858

Product Gene Name

AR-C155858, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

461.53

Solubility

DMSO: 50mg/mL (108.34mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C21H27N5O5S

SMILES

O=C(C1=C2SC(CC3=C(NN=C3C)C)=C1C(N4C[C@@H](CO4)O)=O)N(C(N2CC(C)C)=O)C

CAS Number

496791-37-8

Target & IC50

MCT1: ic50 2.3nM (ki)
MCT2: ic50 10nM (ki)

In Vitro

AR-C155858 (10nM-100nM) inhibits MCT1/MCT2 C-terminal chimaeras[1]. AR-C155858 inhibits MCT1 expressed in Xenopus oocytes in a time- and concentration-dependent manner[2]. AR-C155858 inhibits MCT2, and the 70% inhibition seen at 10nM is followed by a gradually increasing inhibition which can only be explained by a Ki value of significantly less than 10nM.

Product Categories/Family for AR-C155858, inhibitor

Membrane transporter/Ion channel; Monocarboxylate transporter

Product References and Citations for AR-C155858, inhibitor

Ovens MJ, et al. The inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated by the associated ancillary protein. Biochem J. 2010 Oct 15;431(2):217-25.
Ovens MJ, et al. The inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated by the associated ancillary protein. Biochem J. 2010 Oct 15;431(2):217-25.
Ovens MJ, et al. AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10. Biochem J. 2010 Jan 15;425(3):523-30.
Ovens MJ, et al. AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10. Biochem J. 2010 Jan 15;425(3):523-30.
Vijay N, et al. A Novel Monocarboxylate Transporter Inhibitor as a Potential treatment,Strategy for gamma-Hydroxybutyric Acid Overdose. Pharm Res. 2015 Jun;32(6):1894-906.
Vijay N, et al. A Novel Monocarboxylate Transporter Inhibitor as a Potential treatment,Strategy for gamma-Hydroxybutyric Acid Overdose. Pharm Res. 2015 Jun;32(6):1894-906.

Other Notes

Small volumes of AR-C155858, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AR-C155858 purchase

MBS5754530 is an inhibitor targeting AR-C155858.