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Arterolane Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754534

Arterolane is an antimalarial compound. For against P. falciparum Ro73 and W2, the IC50s are both 1.1nM. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Arterolane, Inhibitor
Full Product Name
Arterolane
Product Synonym Names
OZ 277; RBx 11160
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
392.53
Solubility
DMSO: 100mg/mL (254.76mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C22H36N2O4
SMILES
O=C(NCC(N)(C)C)C[C@H](CC1)CC[C@]21OO[C@]3(O2)[C@H]4C[C@@H]5C[C@H](C4)C[C@H]3C5
CAS Number
664338-39-0
Target & IC50
P. falciparum Ro73: ic50 1.1nM
P. falciparum W2: ic50 1.1nM
In Vitro
Arterolane also shows inhibitory activity against several other P. falciparums, with IC50s of 1.0, 1.6, 0.90, 0.91, 1.4, 1.5, 0.83, and 0.84ng/mL for P. falciparum K1, Fc27, FVO, NF54, HB3, FCB1, ITG2-F6, and MAD20, respectively[1]. Arterolane (Trioxolane 7; OZ277; RBx-11160) is an antimalarial agent, with IC50s of both 1.1nM (0.43ng/mL) against P. falciparum Ro73 and W2, respectively.

Structure of Arterolane, inhibitor

Arterolane Inhibitor – Cat# MBS5754534

Product References and Citations for Arterolane, inhibitor

Vennerstrom JL, et al. Identification of an antimalarial synthetic trioxolane drug development candidate. Nature. 2004 Aug 19;430(7002):900-4.
Vennerstrom JL, et al. Identification of an antimalarial synthetic trioxolane drug development candidate. Nature. 2004 Aug 19;430(7002):900-4.

Other Notes

Small volumes of Arterolane, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Arterolane purchase

MBS5754534 is an inhibitor targeting Arterolane.
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