Atabecestat Inhibitor

Name: Atabecestat Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754540
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754540

Atabecestat (JNJ-54861911) is a potent brain-penetrant and orally active beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, achieves robust and high CSF Abeta reduction and it is tolerated and displays a sustained pharmacokinetic (PK)… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Atabecestat, Inhibitor

Full Product Name

Atabecestat

Product Synonym Names

JNJ-54861911

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

367.4

Solubility

DMSO: 250mg/mL (680.46mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C18H14FN5OS

SMILES

O=C(C1=NC=C(C#N)C=C1)NC2=CC=C(F)C([C@@]3(C)N=C(N)SC=C3)=C2

CAS Number

1200493-78-2

Target & IC50

BACE1

Product Categories/Family for Atabecestat, inhibitor

Neuroscience; BACE

Product References and Citations for Atabecestat, inhibitor

Timmers M, et al. Profiling the dynamics of CSF and plasma Abeta reduction after treatment,with JNJ-54861911, a potent oral BACE inhibitor. Alzheimers Dement (N Y). 2016 Aug 24;2(3):202-212.
Timmers M, et al. Profiling the dynamics of CSF and plasma Abeta reduction after treatment,with JNJ-54861911, a potent oral BACE inhibitor. Alzheimers Dement (N Y). 2016 Aug 24;2(3):202-212.

Other Notes

Small volumes of Atabecestat, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Atabecestat purchase

MBS5754540 is an inhibitor targeting Atabecestat.