• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

ATN-224 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754541

ATN-224 inhibits SOD1 activity in endothelial cells, an effect that is dose dependent with an IC50 of 17.5+/-3.7nM. ATN-224 is an oral Cu2+/Zn2+-superoxide dismutase 1 (SOD1) inhibitor. More details

Please Inquire
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ATN-224, Inhibitor
Full Product Name
ATN-224
Product Gene Name
ATN-224, inhibitor
Product Synonym Names
Bis(choline)tetrathiomolybdate
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
432.56
Solubility
DMSO: 50mg/mL (115.59mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C10H28MoN2O2S4
SMILES
OCC[N+](C)(C)C.OCC[N+](C)(C)C.[S-][Mo]([S-])(=S)=S
CAS Number
649749-10-0
Target & IC50
SOD1, in endothelial cells: ic50 17.5 +/- 3.7nM
In Vitro
Inhibition of angiogenesis when ATN-224 is given by oral gavage occurred before there is measurable depletion of copper in either plasma or copper from the Matrigel plug. ATN-224 also significantly (P<0.05) inhibits angiogenesis in the Matrigel plug model in mice either when added directly to the plug or when given by oral gavage. This result shows that ATN-224 inhibits angiogenesis independently of copper depletion[1].

Product References and Citations for ATN-224, inhibitor

Juarez JC, et al. Copper binding by tetrathiomolybdate attenuates angiogenesis and tumor cell proliferation through the inhibition of superoxide dismutase Clin Cancer Res. 2006 Aug 15;12(16):4974-82.
Juarez JC, et al. Copper binding by tetrathiomolybdate attenuates angiogenesis and tumor cell proliferation through the inhibition of superoxide dismutase 1. Clin Cancer Res. 2006 Aug 15;12(16):4974-82.
Lin J, et al. A non-comparative randomized phase II study of 2 doses of ATN-224, a copper/zinc superoxide dismutase inhibitor, in patients with biochemically recurrent hormone-naa¯ve prostate cancer. Urol Oncol. 2013 Jul;31(5):581-8.
Lin J, et al. A non-comparative randomized phase II study of 2 doses of ATN-224, a copper/zinc superoxide dismutase inhibitor, in patients with biochemically recurrent hormone-naa¯ve prostate cancer. Urol Oncol. 2013 Jul;31(5):581-8.

Other Notes

Small volumes of ATN-224, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ATN-224 purchase

MBS5754541 is an inhibitor targeting ATN-224.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000