AZ-23 Inhibitor

Name: AZ-23 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754554
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754554

AZ-23 is an inhibitor of ATP-competitive and Trk kinase A/B/C. For TrkA, TrkB, FGFR1, Flt3, Ret, MuSk, Lck, the IC50s values are 2nM, 8nM, 24nM, 52nM, 55nM, 84nM, 99nM, respectively. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

AZ-23, Inhibitor

Full Product Name

AZ-23

Product Gene Name

AZ-23, inhibitor

Product Synonym Names

AZ23; AZ 23

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

391.83

Solubility

DMSO: 125mg/mL (319.02mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C17H19ClFN7O

SMILES

CC(OC1=CC(NC2=NC(N[C@H](C3=NC=C(F)C=C3)C)=NC=C2Cl)=NN1)C

CAS Number

915720-21-7

Target & IC50

TrkA: ic50 2nM
TrkB: ic50 8nM

In Vitro

AZ-23 shows in vivo TrkA kinase inhibition and efficacy in mice following oral administration in a TrkA-driven allograft model. And it significant tumor growth inhibition in a Trk-expressing xenograft model of neuroblastoma[1].

Product Categories/Family for AZ-23, inhibitor

Tyrosine Kinase/Adaptors; Trk receptor

Product References and Citations for AZ-23, inhibitor

Thress K, et al. Identification and preclinical characterization of AZ-23, a novel, selective, and orally bioavailable inhibitor of the Trk kinase pathway. Mol Cancer Ther. 2009 Jul; 8(7):1818-27.
Thress K, et al. Identification and preclinical characterization of AZ-23, a novel, selective, and orally bioavailable inhibitor of the Trk kinase pathway. Mol Cancer Ther. 2009 Jul; 8(7):1818-27.

Other Notes

Small volumes of AZ-23, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AZ-23 purchase

MBS5754554 is an inhibitor targeting AZ-23.