AZPFKFB326 Inhibitor – Az PFKFB3 26

Name: AZPFKFB326 Inhibitor; Az PFKFB3 26; MyBioSource
Brand: MyBioSource
SKU: MBS5754556
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754556

AZ PFKFB3 26 inhibits PFKFB1 and PFKFB2 with IC50s of 2.06 and 0.384uM, respectively[1]. AZ PFKFB3 26 is a potent and selective inhibitor of the metabolic kinase PFKFB3 with an IC50 of 23nM. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

AZ PFKFB3 26 (AZPFKFB326), Inhibitor

Full Product Name

AZ PFKFB3 26

Product Gene Name

AZPFKFB326, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

402.49

Solubility

DMSO: 5mg/mL (12.42mM) ultrasonic and adjust pH to 3 with HCl
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C24H26N4O2

SMILES

O=C([C@H]1NCCC1)NC2=CC=C(OC3=CC4=C(N(CC(C)C)C=C4C#N)C=C3)C=C2

CAS Number

1704740-52-2

Target & IC50

PFKFB3: ic50 23nM
PFKFB1: ic50 2.06uM
PFKFB2: ic50 0.384uM

Product Categories/Family for AZPFKFB326, inhibitor

Metabolism; Glucokinase

Product References and Citations for AZPFKFB326, inhibitor

Boyd S, et al. Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase PFKFB3. J Med Chem. 2015 Apr 23;58(8):3611-25.
Boyd S, et al. Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase PFKFB3. J Med Chem. 2015 Apr 23;58(8):3611-25.

Other Notes

Small volumes of AZPFKFB326, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AZPFKFB326 purchase

MBS5754556 is an inhibitor targeting AZPFKFB326. Also known as AZ PFKFB3 26.