AZ1495 Inhibitor

Name: AZ1495 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754557
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754557

AZ1495 is an oral active Interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor(IC50 of 5nM and 23nM for IRAK4 and IRAK1, respectively). More details

Please Inquire

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

AZ1495, Inhibitor

Full Product Name

AZ1495

Product Gene Name

AZ1495, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

385.5

Solubility

DMSO: 10mg/mL (25.94mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C21H31N5O2

SMILES

C1(C(C2CCOCC2)=CN3)=C3N=CN=C1N[C@@H]4CC[C@@H](N5CCOCC5)CC4

CAS Number

2196204-23-4

Target & IC50

IRAK4: ic50 5nM
IRAK1: ic50 23nM
CLK1: ic50 50nM
CLK2: ic50 5nM
CLK4: ic50 8nM
haspin: ic50 4nM

Product Categories/Family for AZ1495, inhibitor

Cell Cycle/Checkpoint; CDK

Product References and Citations for AZ1495, inhibitor

Scott JS, et al. Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin-1 Receptor Associated Kinase 4 (IRAK4) for the treatment,of Mutant MYD88L265P Diffuse Large B-Cell Lymphoma. J Med Chem. 2017 Dec 28;60(24):10071-10091.
Scott JS, et al. Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin-1 Receptor Associated Kinase 4 (IRAK4) for the treatment,of Mutant MYD88L265P Diffuse Large B-Cell Lymphoma. J Med Chem. 2017 Dec 28;60(24):10071-10091.

Other Notes

Small volumes of AZ1495, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AZ1495 purchase

MBS5754557 is an inhibitor targeting AZ1495.