AZD1152 Inhibitor

Name: AZD1152 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754559
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754559

AZD1152 is a pro-drug of Barasertib-hQPA, which is a highly selective inhibitor of Aurora B (IC50:0.37nM, in a cell-free assay). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

AZD1152, Inhibitor

Full Product Name

AZD1152

Product Gene Name

AZD1152, inhibitor

Product Synonym Names

Barasertib

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

587.54

Solubility

DMSO: 33mg/mL (56.17mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C26H31FN7O6P

SMILES

O=C(NC1=CC=CC(F)=C1)CC2=CC(NC3=C4C=CC(OCCCN(CC)CCOP(O)(O)=O)=CC4=NC=N3)=NN2

CAS Number

722543-31-9

Target & IC50

Aurora B: ic50 0.37nM

In Vitro

Administration of AZD1152 (25mg/kg) alone markedly suppresses the growth of MOLM13 xenografts, confirmed by the observation of necrotic tissue with infiltration of phagocytic cells[1]. AZD1152 (25mg/kg/day) treatment,reduces xenograft levels such that they are slightly lower levels than after the first round of treatment, but this is not statistically significant indicating that residual cells might be more resistant to a second cycle of AZD1152[4]. In addition, AZD1152 (10-150mg/kg/day) significantly inhibits the growth of a variety of human solid tumor xenografts, including colon, breast, and lung cancers, in a dose-dependent manner[2].

Product Categories/Family for AZD1152, inhibitor

Cell Cycle/Checkpoint; Aurora Kinase; Chromatin/Epigenetic

Product References and Citations for AZD1152, inhibitor

Yang J, et al. AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo. Blood. 2007 Sep
Yang J, et al. AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo. Blood. 2007 Sep
Wilkinson RW, et al. AZD1152, a selective inhibitor of Aurora B kinase, inhibits human tumor xenograft growth by inducing apoptosis. Clin Cancer Res. 2007 Jun 15;13(12):3682-8.
Wilkinson RW, et al. AZD1152, a selective inhibitor of Aurora B kinase, inhibits human tumor xenograft growth by inducing apoptosis. Clin Cancer Res. 2007 Jun 15;13(12):3682-8.
Evans RP, et al. The selective Aurora B kinase inhibitor AZD1152 is a potential new treatment, for multiple myeloma. Br J Haematol. 2008 Feb;140(3):295-302.
Evans RP, et al. The selective Aurora B kinase inhibitor AZD1152 is a potential new treatment, for multiple myeloma. Br J Haematol. 2008 Feb;140(3):295-302.
Oke A, et al. AZD1152 rapidly and negatively affects the growth and survival of human acute myeloid leukemia cells in vitro and in vivo. Cancer Res. 2009 May 15;69(10):4150-8.
Oke A, et al. AZD1152 rapidly and negatively affects the growth and survival of human acute myeloid leukemia cells in vitro and in vivo. Cancer Res. 2009 May 15;69(10):4150-8.

Other Notes

Small volumes of AZD1152, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AZD1152 purchase

MBS5754559 is an inhibitor targeting AZD1152.