AZD2906 Inhibitor

Name: AZD2906 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754560
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754560

AZD2906 shows IC50s of 2.2, 0.3, 41.6 and 7.5nM at GR in human, rat PBMC and human, rat whole blood, respectively[1]. AZD2906 is a selective glucocorticoid receptor (GR) agonist, increases micronucleated immature erythrocytes in the bone marrow of rats. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

AZD2906, Inhibitor

Full Product Name

AZD2906

Product Gene Name

AZD2906, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

460.5

Solubility

DMSO: 125mg/mL (271.44mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C26H25FN4O3

SMILES

FC1=CC=C(N2N=CC3=CC(O[C@@H]([C@@H](NC(C4CC4)=O)C)C5=CC=C(N=C5)OC)=CC=C23)C=C1

CAS Number

1034148-15-6

Target & IC50

Glucocorticoid receptor, Human PBMC: ic50 2.2nM
Glucocorticoid receptor, Rat PBMC: ic50 0.3nM
Glucocorticoid receptor, Human whole blood: ic50 41.6nM
Glucocorticoid receptor, Rat whole blood: ic50 7.5nM

In Vitro

AZD2906 (5, 25, 50mg/kg, p.o.) increases micronucleated immature erythrocytes (MIE) in the bone marrow of rats after treatment, for 2 days[1]. AZD2906 (5, 25mg/kg, p.o.) induces an accumulation of glycogen in the liver of rats. And it exhibits cortical lymphocytic atrophy of a moderate to marked degree in the thymus of rats[1].

Product Categories/Family for AZD2906, inhibitor

Metabolism; GR

Product References and Citations for AZD2906, inhibitor

Hayes JE, et al. Micronucleus induction in the bone marrow of rats by pharmacological mechanisms. I: glucocorticoid receptor agonism. Mutagenesis. 2013 Mar;28(2):227-32.
Hayes JE, et al. Micronucleus induction in the bone marrow of rats by pharmacological mechanisms. I: glucocorticoid receptor agonism. Mutagenesis. 2013 Mar;28(2):227-32.

Other Notes

Small volumes of AZD2906, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AZD2906 purchase

MBS5754560 is an inhibitor targeting AZD2906.