AZD8329 Inhibitor

Name: AZD8329 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754568
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754568

AZD8329 is a potent inhibitor of 11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1)(IC50 of 9nM for human 11beta-HSD1), and displays excellent selectivity versus 11beta-HSD2, 17beta-HSD1 and 17beta-HSD3. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

AZD8329, Inhibitor

Full Product Name

AZD8329

Product Gene Name

AZD8329, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

421.53

Solubility

DMSO: 62.5mg/mL (148.27mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C25H31N3O3

SMILES

O=C(O)C1=CC=C(N2N=CC(C(NC3C(C4)CC5CC4CC3C5)=O)=C2C(C)(C)C)C=C1

CAS Number

1048668-70-7

Target & IC50

Human 11beta-HSD1: ic50 9nM

Product Categories/Family for AZD8329, inhibitor

Metabolism; Dehydrogenase

Product References and Citations for AZD8329, inhibitor

Scott JS, et al. Novel acidic 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitor with reduced acyl glucuronide liability: the discovery of 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid (AZD8329). J Med Chem. 2012 Nov 26;55(22):10136-47.
Scott JS, et al. Novel acidic 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitor with reduced acyl glucuronide liability: the discovery of 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid (AZD8329). J Med Chem. 2012 Nov 26;55(22):10136-47.

Other Notes

Small volumes of AZD8329, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AZD8329 purchase

MBS5754568 is an inhibitor targeting AZD8329.