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Balovaptan Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754576

Balovaptan (RG7314) is a highly potent and selective brain-penetrant vasopressin 1a (hV1a) receptor antagonist, with Kis of 1 and 39nM for human (hV1a) and mouse (mV1a) receptors. It is used for the research of autism. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Balovaptan, Inhibitor
Full Product Name
Balovaptan
Product Synonym Names
RG7314
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
409.91
Solubility
DMSO: 62.5mg/mL (152.47mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C22H24ClN5O
SMILES
CN1CC2=NN=C([C@H]3CC[C@H](OC4=NC=CC=C4)CC3)[N@]2[C@]5=CC=C(Cl)C=C5C1
CAS Number
1228088-30-9
Target & IC50
hV1a: ic50 1nM (ki)
mV1a: ic50 39nM (ki)
In Vitro
Balovaptan (RG7314) is a highly potent and selective brain-penetrant vasopressin 1a (hV1a) receptor antagonist, with Kis of 1 and 39nM for hV1a and mhV1a. It is used for the research of autism. Balovaptan shows >30000-fold selectivity for hV1a over hV2 receptors, 9891-fold selectivity over hOTR (human oxytocin receptor)[1].

Structure of Balovaptan, inhibitor

Balovaptan Inhibitor – Cat# MBS5754576

Product References and Citations for Balovaptan, inhibitor

Ratni H, et al. Discovery of highly selective brain-penetrant vasopressin 1a antagonists for the potential treatment,of autism via a chemogenomic and scaffold hopping approach. J Med Chem. 2015 Mar 12;58(5):2275-89.
Ratni H, et al. Discovery of highly selective brain-penetrant vasopressin 1a antagonists for the potential treatment,of autism via a chemogenomic and scaffold hopping approach. J Med Chem. 2015 Mar 12;58(5):2275-89.

Other Notes

Small volumes of Balovaptan, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Balovaptan purchase

MBS5754576 is an inhibitor targeting Balovaptan.
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