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Barbadin Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754580

Barbadin is a novel and selective beta-arrestin/beta2-adaptin interaction inhibitor. It has IC50 values of 19.1uM for beta-arrestin1 and 15.6uM for beta-arrestin2. Barbadin blocks agonist-promoted endocytosis of the prototypical beta-adrenergic,… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Barbadin, Inhibitor
Full Product Name
Barbadin
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
333.41
Solubility
DMSO: 50mg/mL (149.97mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C19H15N3OS
SMILES
O=C1C(C(C2=CC=C(CC3=CC=CC=C3)C=C2)=CS4)=C4N=CN1N
CAS Number
356568-70-2
Target & IC50
beta-arrestin1: ic50 19.1uM
beta-arrestin2: ic50 15.6uM

Structure of Barbadin, inhibitor

Barbadin Inhibitor – Cat# MBS5754580

Product References and Citations for Barbadin, inhibitor

Beautrait A, et al. A new inhibitor of the beta-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling. Nat Commun. 2017 Apr 18;8:15054. doi: 10.1038/ncomms15054.
Beautrait A, et al. A new inhibitor of the beta-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling. Nat Commun. 2017 Apr 18;8:15054. doi: 10.1038/ncomms15054.

Other Notes

Small volumes of Barbadin, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Barbadin purchase

MBS5754580 is an inhibitor targeting Barbadin.
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