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BAY-850 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754586

BAY-850 is a potent and isoform selective ATPase family AAA domain-containing protein 2 (ATAD2) inhibitor. With an IC50 of 166nM. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
BAY-850, Inhibitor
Full Product Name
BAY-850
Product Gene Name
BAY-850, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
654.24
Solubility
DMSO: 62.5mg/mL (95.53mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C38H44ClN5O3
SMILES
O=C(N[C@H](CC1=CC=C(C#N)C=C1)CN[C@H]2CC[C@@H](N)CC2)C3=CC(C4=CC=C(CN[C@@H](C5=CC=C(C)C=C5)C)O4)=C(OC)C=C3Cl
CAS Number
2099142-76-2
Target & IC50
ATAD2
In Vitro
BAY-850 displaces the tetra-acetylated peptide with an IC50 of 157nM and a KD of 115nM respectively. BAY-850 competes with the binding of a mono-acetylated Histone H4 N-terminal peptide to ATAD2 BD with an IC50 of 166nM measured in TR-FRET assay. The unprecedented isoform selectivity of BAY-850 suggests a different mode of action to those exhibited by canonical BD inhibitors[1].

Structure of BAY-850, inhibitor

BAY-850 Inhibitor – Cat# MBS5754586

Product References and Citations for BAY-850, inhibitor

Fernandez-Montalvan AE, et al. Isoform-Selective ATAD2 Chemical Probe with Novel Chemical Structure and Unusual Mode of Action. ACS Chem Biol. 2017 Nov 17;12(11):2730-2736.
Fernandez-Montalvan AE, et al. Isoform-Selective ATAD2 Chemical Probe with Novel Chemical Structure and Unusual Mode of Action. ACS Chem Biol. 2017 Nov 17;12(11):2730-2736.

Other Notes

Small volumes of BAY-850, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BAY-850 purchase

MBS5754586 is an inhibitor targeting BAY-850.
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