BAY1082439 Inhibitor

Name: BAY1082439 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754587
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754587

BAY1082439 is a selective and orally bioavailable inhibitor of PI3Kalpha/beta/delta, and also inhibits mutated forms of PIK3CA, with highly effective in inhibiting Pten-null prostate cancer growth. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

BAY1082439, Inhibitor

Full Product Name

BAY1082439

Product Gene Name

BAY1082439, inhibitor

Form/Format

Solid. Powder

Purity/Purification

100.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

494.54

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C25H30N6O5

SMILES

COc1c(OC[C@H](O)CN2CCOCC2)ccc2C3=NCCN3C(NC(=O)c3cccnc3C)=Nc12

CAS Number

1375469-38-7

Target & IC50

PI3Kalpha
PI3Kbeta
PI3Kdelta

In Vitro

BAY1082439 (75mg/kg; p.o.; daily for 4 weeks) is effective in preventing Pten-null prostate cancer progression[2].

Product Categories/Family for BAY1082439, inhibitor

PI3K/Akt/mTOR signaling; PI3K

Product References and Citations for BAY1082439, inhibitor

Ningshu Liu, et al. Abstract 2799: BAY 1082439, a highly selective and balanced PI3Kalpha/beta inhibitor demonstrated potent activity in tumors with activated PI3Kalpha and loss-of-function of PTEN. Abstract nr 2799. doi:1538-7445. AM2012-2799.
Ningshu Liu, et al. Abstract 2799: BAY 1082439, a highly selective and balanced PI3Kalpha/beta inhibitor demonstrated potent activity in tumors with activated PI3Kalpha and loss-of-function of PTEN. Abstract nr 2799. doi:1538-7445. AM2012-2799.
Yongkang Zou, et al. Co-Targeting the Cell Intrinsic and Microenvironment Pathways of Prostate Cancer by PI3Kalpha/beta/delta inhibitor BAY1082439. Mol Cancer Ther. 2018 Oct;17(10):2091-2099.
Yongkang Zou, et al. Co-Targeting the Cell Intrinsic and Microenvironment Pathways of Prostate Cancer by PI3Kalpha/beta/delta inhibitor BAY1082439. Mol Cancer Ther. 2018 Oct;17(10):2091-2099.

Other Notes

Small volumes of BAY1082439, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BAY1082439 purchase

MBS5754587 is an inhibitor targeting BAY1082439.