Begacestat Inhibitor

Begacestat is a selective thiophene sulfonamide amyloid precursor protein gamma-secretase inhibitor (Abeta40,IC50=15nM), and for the treatment,of Alzheimer's disease.

Mayer SC, et al. Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment,of Alzheimer's disease. J Med Chem. 2008 Dec 11;51(23):7348-51.
Mayer SC, et al. Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment,of Alzheimer's disease. J Med Chem. 2008 Dec 11;51(23):7348-51.
Martone RL, et al. Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment,of Alzheimer's disease. J Pharmacol Exp Ther. 2009 Nov;331(2):598-608.
Martone RL, et al. Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment,of Alzheimer's disease. J Pharmacol Exp Ther. 2009 Nov;331(2):598-608.

Small volumes of Begacestat, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5754591 is an inhibitor targeting Begacestat.