JWG-071 Inhibitor

Name: JWG-071 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754597
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754597

JWG-071 is the first reported kinase-selective chemical probe for ERK5. JWG-071 will be a much-needed chemical probe for deconvoluting ERK5 and BRD4 pharmacology[1]. JWG-071 improves ERK5 activity and BRD4 selectivity. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

JWG-071, Inhibitor

Full Product Name

JWG-071

Product Gene Name

JWG-071, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

612.76

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C34H44N8O3

SMILES

COC1=CC(C(N2CCC(N3CCN(C)CC3)CC2)=O)=CC=C1NC4=NC=C(N(C)C5=O)C(N(C6=CC=CC=C65)C(C)CC)=N4

CAS Number

2250323-50-1

Target & IC50

ERK5: ic50

In Vitro

JWG-071 inhibits ERK5 and LRRK2 with IC50 of 88 and 109nM, respectively[1].

Product Categories/Family for JWG-071, inhibitor

MAPK; ERK

Product References and Citations for JWG-071, inhibitor

Wang J, et al. Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinonesas Inhibitors of Kinases and Bromodomains. ACS Chem Biol. 2018 Sep 21;13(9):2438-2448
Wang J, et al. Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinonesas Inhibitors of Kinases and Bromodomains. ACS Chem Biol. 2018 Sep 21;13(9):2438-2448

Other Notes

Small volumes of JWG-071, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for JWG-071 purchase

MBS5754597 is an inhibitor targeting JWG-071.