Bimosiamose Inhibitor

Name: Bimosiamose Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754613
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754613

Bimosiamose has anti-inflammatory effects[1]. Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 uM, 20uM, and 86uM for E-selectin, L-selectin, and P-selectin respectively. More details

Please Inquire

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Bimosiamose, Inhibitor

Full Product Name

Bimosiamose

Product Synonym Names

TBC-1269

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

862.91

Solubility

DMSO: 125mg/mL (144.86mM) Need ultrasonic
0.1 M NaOH: 25mg/mL (28.97mM) ultrasonic and adjust pH to 10 with NaOH
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C46H54O16

SMILES

OC[C@H]([C@@H](O)[C@H](O)[C@@H]1O)O[C@@H]1OC(C=C2)=C(C3=CC(CC(O)=O)=CC=C3)C=C2CCCCCCC(C=C4)=CC(C5=CC(CC(O)=O)=CC=C5)=C4O[C@H]6O[C@@H]([C@@H](O)[C@H](O)[C@@H]6O)CO

CAS Number

187269-40-5

Target & IC50

E-selectin: ic50 88uM
P-selectin: ic50 20uM
L-selectin: ic50 86uM

In Vitro

Bimosiamose (TBC-1269; 25mg/kg; intravenous injection; Sprague-Dawley rats) treatment,shows a significant increase in survival. Neutrophil migration is also significantly ameliorated (81%). The histologic damage scores is also improved[1]. Best overall survival, 70%, is observed when TBC-1269 is administered 15 minutes before reperfusion. It also shows a marked decrease in liver enzyme levels at 6 hours after reperfusion.

Product Categories/Family for Bimosiamose, inhibitor

Cytoskeletal Signaling; Integrin

Product References and Citations for Bimosiamose, inhibitor

Palma-Vargas JM, et al. Small-molecule selectin inhibitor protects against liver inflammatory response after ischemia and reperfusion. J Am Coll Surg. 1997 Oct;185(4):365-72.
Palma-Vargas JM, et al. Small-molecule selectin inhibitor protects against liver inflammatory response after ischemia and reperfusion. J Am Coll Surg. 1997 Oct;185(4):365-72.

Other Notes

Small volumes of Bimosiamose, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Bimosiamose purchase

MBS5754613 is an inhibitor targeting Bimosiamose.