BIP-135 Inhibitor

Name: BIP-135 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754617
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754617

BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor. With IC50s of 16nM and 21nM for GSK-3alpha and GSK-3beta, respectively. BIP 135 exhibits neuroprotective effect[1]. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

BIP-135, Inhibitor

Full Product Name

BIP-135

Product Gene Name

BIP-135, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

421.24

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C21H13BrN2O3

SMILES

O=C(C(C1=COC2=CC=CC=C12)=C3C4=CN(C)C5=C4C=C(Br)C=C5)NC3=O

CAS Number

941575-71-9

Target & IC50

GSK-3alpha: ic50 16nM
GSK-3beta: ic50 21nM

Product Categories/Family for BIP-135, inhibitor

PI3K/Akt/mTOR signaling; GSK-3; Stem Cells

Product References and Citations for BIP-135, inhibitor

Chen PC, et al. Identification of a Maleimide-Based Glycogen Synthase Kinase-3 (GSK-3) Inhibitor, BIP-135, that Prolongs the Median Survival Time of delta7 SMA KO Mouse Model of Spinal Muscular Atrophy. ACS Chem Neurosci. 2012 Jan 18;3(1):5-11.
Chen PC, et al. Identification of a Maleimide-Based Glycogen Synthase Kinase-3 (GSK-3) Inhibitor, BIP-135, that Prolongs the Median Survival Time of delta7 SMA KO Mouse Model of Spinal Muscular Atrophy. ACS Chem Neurosci. 2012 Jan 18;3(1):5-11.

Other Notes

Small volumes of BIP-135, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BIP-135 purchase

MBS5754617 is an inhibitor targeting BIP-135.