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BMS-509744 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754625

MBS5754625 is an inhibitor targeting BMS-509744. BMS-509744 is an inhibitor of ATP competitive Itk (IC50: 19nM). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
BMS-509744, Inhibitor
Full Product Name
BMS-509744
Product Gene Name
BMS-509744, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
623.83
Solubility
DMSO: 21.9mg/mL (35.11mM) Need ultrasonic and warming
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C32H41N5O4S2
SMILES
CC(C(C)(C)C)NCC1=CC=C(C(NC2=NC=C(SC3=CC(C(N4CCN(C(C)=O)CC4)=O)=C(OC)C=C3C)S2)=O)C=C1
CAS Number
439575-02-7
Target & IC50
Itk: ic50 19nM
In Vitro
BMS-509744 exhibits a 50% inhibitory capacity when dosed at 50mg/kg, irrespective of the amount of induction antibody. BMS-509744 and BMS-488516 suppress the production of IL-2 induced by anti-T-cell receptor antibody administered to mice. BMS-509744 also significantly diminishes lung inflammation in a mouse model of ovalbumin-induced allergy/asthma[1].

Product Categories/Family for BMS-509744, inhibitor

Metabolism; Others

Structure of BMS-509744, inhibitor

BMS-509744 Inhibitor – Cat# MBS5754625

Product References and Citations for BMS-509744, inhibitor

Lin TA, et al. Selective Itk inhibitors block T-cell activation and murine lung inflammation. Biochemistry.2004 Aug 31;43(34):11056-62.
Lin TA, et al. Selective Itk inhibitors block T-cell activation and murine lung inflammation. Biochemistry.2004 Aug 31;43(34):11056-62.

Other Notes

Small volumes of BMS-509744, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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