BMS-564929 Inhibitor

Solid. Powder

98.00%

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

305.72

DMSO: 50mg/mL (163.55mM) Need ultrasonic
H2O: <0.1mg/mL (insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)

C14H12ClN3O3

N#CC1=CC=C(N(C(N2[C@@]3([H])[C@H](O)CC2)=O)C3=O)C(C)=C1Cl

627530-84-1

Androgen receptor: ic50 2.11+/-0.16nM (ki)

BMS-564929 is more than 200 times more potent in stimulation of muscle and 80 times more selective for muscle vs. prostate, compared with T propionate (TP) in the same model[1]. BMS-564929 (p.o.) shows substantially more potent activity in the levator ani, exhibiting an ED50 of 0.0009mg/kg in the levator ani and an ED50 of 0.14mg/kg in the prostate; a net 160-fold selectivity for muscle vs. prostate, in sexually mature, castrated male rats, a well-characterized animal model. Approximately 100% muscle stimulation is achieved at 0.1mg/kg, reaching greater than 125% stimulation at 0.3 and 1mg/kg.

Endocrinology/Hormones; Androgen Receptor