BMS-690514 Inhibitor

Name: BMS-690514 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754628
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754628

BMS-690514 is a potent and orally active inhibitor of EGFR and VEGFR. It has IC50s of 5, 20 and 60nM for EGFR, HER 2 and HER 4, respectively. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

BMS-690514, Inhibitor

Full Product Name

BMS-690514

Product Gene Name

BMS-690514, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

368.43

Solubility

DMSO: 25mg/mL (67.86mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C19H24N6O2

SMILES

O[C@@H]1CN(CC[C@H]1N)CC2=C3C(NC4=CC=CC(OC)=C4)=NC=NN3C=C2

CAS Number

859853-30-8

Target & IC50

EGFR: ic50 5nM
HER2: ic50 20nM
HER4: ic50 60nM

Product Categories/Family for BMS-690514, inhibitor

Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors

Product References and Citations for BMS-690514, inhibitor

Wong TW, et al. Antitumor and antiangiogenic activities of BMS-690514, an inhibitor of human EGF and VEGF receptor kinase families. Clin Cancer Res. 2011 Jun 15;17(12):4031-4
Wong TW, et al. Antitumor and antiangiogenic activities of BMS-690514, an inhibitor of human EGF and VEGF receptor kinase families. Clin Cancer Res. 2011 Jun 15;17(12):4031-41.
Marathe P, et al. Preclinical pharmacokinetics and in vitro metabolism of BMS-690514, a potent inhibitor of EGFR and VEGFRJ Pharm Sci. 2010 Aug;99(8):3579-93.
Marathe P, et al. Preclinical pharmacokinetics and in vitro metabolism of BMS-690514, a potent inhibitor of EGFR and VEGFR2. J Pharm Sci. 2010 Aug;99(8):3579-93.

Other Notes

Small volumes of BMS-690514, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BMS-690514 purchase

MBS5754628 is an inhibitor targeting BMS-690514.