CDK2-IN-4 Inhibitor

Name: CDK2-IN-4 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754690
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754690

CDK2-IN-4 is a potent and selective inhibitor of CDK2 with an IC50 of 44nM for CDK2/cyclin A. It shows 2,000-fold selectivity over CDK1/cyclin B with IC50 of 86uM. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CDK2-IN-4, Inhibitor

Full Product Name

CDK2-IN-4

Product Gene Name

CDK2-IN-4, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

442.49

Solubility

DMSO: 19.83mg/mL (44.81mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C23H18N6O2S

SMILES

NS(=O)(=O)c1ccc(Nc2nc(-c3cccc(c3)-c3ccccc3)c3nc[nH]c3n2)cc1

CAS Number

2079895-42-2

Target & IC50

cdk2/cyclin A: ic50 44nM
Cdk1/cyclin B: ic50 86uM

Product Categories/Family for CDK2-IN-4, inhibitor

Cell Cycle/Checkpoint; CDK

Product References and Citations for CDK2-IN-4, inhibitor

Coxon CR, et al. Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines. J Med Chem. 2017 Mar 9;60(5):1746-1767.
Coxon CR, et al. Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines. J Med Chem. 2017 Mar 9;60(5):1746-1767.

Other Notes

Small volumes of CDK2-IN-4, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CDK2-IN-4 purchase

MBS5754690 is an inhibitor targeting CDK2-IN-4.