Elexacaftor Inhibitor

Name: Elexacaftor Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754701
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754701

Elexacaftor is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR) and also facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Elexacaftor, Inhibitor

Full Product Name

Elexacaftor

Product Synonym Names

VX-445

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

597.65

Solubility

DMSO: 125mg/mL (209.15mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C26H34F3N7O4S

SMILES

CC1(C)C[C@H](C)CN1C2=C(C(NS(C3=CN(C)N=C3C)(=O)=O)=O)C=CC(N4C=CC(OCC(C)(C(F)(F)F)C)=N4)=N2

CAS Number

2216712-66-0

Target & IC50

CFTR

In Vitro

Elexacaftor (VX-445) has the potential to treat cystic fibrosis. VX-445-Tezacaftor-VX-770 significantly improves Phe508del CFTR protein processing, trafficking, and chloride transport to a greater extent than any two of these agents in dual combination [2].

Product Categories/Family for Elexacaftor, inhibitor

Membrane transporter/Ion channel; CFTR

Product References and Citations for Elexacaftor, inhibitor

Alexander Russell Abela, et al. MODULATOR OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR, PHARMACEUTICAL COMPOSITIONS, METHODS OF treatment, AND PROCESS FOR MAKING THE MODULATOR. US 20180162839 A1.
Alexander Russell Abela, et al. MODULATOR OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR, PHARMACEUTICAL COMPOSITIONS, METHODS OF treatment, AND PROCESS FOR MAKING THE MODULATOR. US 20180162839 A1.
Keating D, et al. VX-445-Tezacaftor-VX-770 in Patients with Cystic Fibrosis and One or Two Phe508del Alleles. N Engl J Med. 2018 Oct 25;379(17):1612-1620.
Keating D, et al. VX-445-Tezacaftor-VX-770 in Patients with Cystic Fibrosis and One or Two Phe508del Alleles. N Engl J Med. 2018 Oct 25;379(17):1612-1620.

Other Notes

Small volumes of Elexacaftor, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Elexacaftor purchase

MBS5754701 is an inhibitor targeting Elexacaftor.