CHR-6494 Inhibitor

Name: CHR-6494 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754711
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754711

CHR-6494 is a haspin inhibitor that inhibits histone H3T3 phosphorylation (IC50: 2nM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CHR-6494, Inhibitor

Full Product Name

CHR-6494

Product Gene Name

CHR-6494, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

292.34

Solubility

DMSO: 50mg/mL (171.03mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C16H16N6

SMILES

CCCNC(C=C1)=NN2C1=NC=C2C3=CC(C=NN4)=C4C=C3

CAS Number

1333377-65-3

Target & IC50

haspin: ic50 2nM

Product Categories/Family for CHR-6494, inhibitor

Cell Cycle/Checkpoint

Product References and Citations for CHR-6494, inhibitor

Huertas D, et al. Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin. Oncogene. 2012 Mar 15;31(11):1408-18.
Huertas D, et al. Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin. Oncogene. 2012 Mar 15;31(11):1408-18.
Han L, et al. Anti-Melanoma Activities of Haspin Inhibitor CHR-6494 Deployed as a Single Agent or in a Synergistic Combination with MEK Inhibitor. J Cancer. 2017 Aug 25;8(15):2933-2943.
Han L, et al. Anti-Melanoma Activities of Haspin Inhibitor CHR-6494 Deployed as a Single Agent or in a Synergistic Combination with MEK Inhibitor. J Cancer. 2017 Aug 25;8(15):2933-2943.

Other Notes

Small volumes of CHR-6494, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CHR-6494 purchase

MBS5754711 is an inhibitor targeting CHR-6494.