CMPD1 Inhibitor

CMPD1 is a non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor (apparent Ki (Kiapp): 330nM).

Gurgis F, et al. Cytotoxic activity of the MK2 inhibitor CMPD1 in glioblastoma cells is independent of MK2. Cell Death Discov. 2015 Sep 7;1:15028.
Gurgis F, et al. Cytotoxic activity of the MK2 inhibitor CMPD1 in glioblastoma cells is independent of MK2. Cell Death Discov. 2015 Sep 7;1:15028.
Davidson W, er al. Discovery and characterization of a substrate selective p38alpha inhibitor. Biochemistry.2004 Sep 21;43(37):11658-71.
Davidson W, er al. Discovery and characterization of a substrate selective p38alpha inhibitor. Biochemistry.2004 Sep 21;43(37):11658-71.
Phoa AF, et al. Pharmacology of novel small-molecule tubulin inhibitors in glioblastoma cells with enhanced EGFR signalling. Biochem Pharmacol. 2015 Dec 15;98(4):587-601.
Phoa AF, et al. Pharmacology of novel small-molecule tubulin inhibitors in glioblastoma cells with enhanced EGFR signalling. Biochem Pharmacol. 2015 Dec 15;98(4):587-601.

Small volumes of CMPD1, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5754728 is an inhibitor targeting CMPD1.