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Rociletinib hydrobromide Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754732

Rociletinib hydrobromide is an orally delivered inhibitor of the mutant form of EGFR kinase (Kis: 21.5nM and 303.3nM for EGFR L858R/T790M and EGFR WT). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Rociletinib hydrobromide, Inhibitor
Full Product Name
Rociletinib hydrobromide
Product Synonym Names
CO-1686 (hydrobromide); AVL-301 hydrobromide; CNX-419 hydrobromide
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
636.46
Solubility
DMSO: 59mg/mL (92.70mM)
H2O: <0.1mg/mL (insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C27H29BrF3N7O3
SMILES
C=CC(NC1=CC=CC(NC2=NC(NC3=CC=C(N4CCN(C(C)=O)CC4)C=C3OC)=NC=C2C(F)(F)F)=C1)=O.[H]Br
CAS Number
1446700-26-0
Target & IC50
EGFRL858R/T790M: ic50 21.5nM (ki)
EGFRT790M: ic50 303.3nM (ki)
In Vitro
Rociletinib (50mg/kg bid, p.o.) shows anti-tumor activity in human EGFR-L858R and EGFR-L858R-T790M expressing transgenic mice. Rociletinib (100mg/kg/day, p.o.) displays anti-tumor activity in NSCLC EGFR mutant xenograft models.

Structure of Rociletinib hydrobromide, inhibitor

Rociletinib hydrobromide Inhibitor – Cat# MBS5754732

Product References and Citations for Rociletinib hydrobromide, inhibitor

Walter AO, et al. Discovery of a mutant-selective covalent inhibitor of EGFR that overcomes T790M-mediated resistance in NSCLC. Cancer Discov. 2013 Sep 25.
Walter AO, et al. Discovery of a mutant-selective covalent inhibitor of EGFR that overcomes T790M-mediated resistance in NSCLC. Cancer Discov. 2013 Sep 25.

Other Notes

Small volumes of Rociletinib hydrobromide, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Rociletinib hydrobromide purchase

MBS5754732 is an inhibitor targeting Rociletinib hydrobromide.
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