CU-T12-9 Inhibitor

Name: CU-T12-9 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754746
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754746

CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9nM in HEK-Blue hTLR2 SEAP assay). It acts by activating the NFkB pathway, upregulating proinflammatory cytokines, and enhancing TLR1 and TLR2 dimerization.CU-T12-9 activates both the innate and the adaptive… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CU-T12-9, Inhibitor

Full Product Name

CU-T12-9

Product Gene Name

CU-T12-9, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

362.31

Solubility

DMSO: 250mg/mL (690.02mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C17H13F3N4O2

SMILES

CNC1=CC=C(C=C1N2C=C(N=C2)C3=CC=C(C=C3)C(F)(F)F)[N+]([O-])=O

CAS Number

1821387-73-8

Target & IC50

TLR2: ic50 52.9nM (EC50) (in HEK-Blue cells)
TLR1: ic50 52.9nM (EC50) (in HEK-Blue cells)

Product Categories/Family for CU-T12-9, inhibitor

Immunology/Inflammation; TLR

Product References and Citations for CU-T12-9, inhibitor

Cheng K, et al. Specific activation of the TLR1-TLR2 heterodimer by small-molecule agonists. Sci Adv. 2015;1(3). pii: e1400139.
Cheng K, et al. Specific activation of the TLR1-TLR2 heterodimer by small-molecule agonists. Sci Adv. 2015;1(3). pii: e1400139.

Other Notes

Small volumes of CU-T12-9, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CU-T12-9 purchase

MBS5754746 is an inhibitor targeting CU-T12-9.