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CUDC-427 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754747

CUDC-427 is an antagonist of second-generation pan-selective IAP used for the treatment,of various cancers. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CUDC-427, Inhibitor
Full Product Name
CUDC-427
Product Gene Name
CUDC-427, inhibitor
Product Synonym Names
GDC-0917
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
564.7
Solubility
DMSO: 100mg/mL (177.09mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C29H36N6O4S
SMILES
O=C([C@H](CCC1)N1C([C@H](C2CCCCC2)NC([C@H](C)NC)=O)=O)NC3=C(C4=CC=CC=C4)N=C(C5=NC=CO5)S3
CAS Number
1446182-94-0
Target & IC50
Others
In Vitro
GDC-0917 is well tolerated, with all dose groups experiencing a <11% decrease in mean body weight. GDC-0917 (0.08-16.3mg/kg) shows antitumor activity in a dose-dependent manner in the MDA-MB-231-X1.1 Breast Cancer Xenograft. GDC-0917 has low to moderate clearance in the mouse (12.0mL/min/kg), rat (27.0mL/min/kg), and dog (15.3mL/min/kg), and high clearance in the monkey (67.6mL/min/kg).

Structure of CUDC-427, inhibitor

CUDC-427 Inhibitor – Cat# MBS5754747

Product References and Citations for CUDC-427, inhibitor

Wong H, et al. Learning and confirming with preclinical studies: modeling and simulation in the discovery of GDC-0917, an inhibitor of apoptosis proteins antagonist. Drug Metab Dispos. 2013 Dec;41(12):2104-13.
Wong H, et al. Learning and confirming with preclinical studies: modeling and simulation in the discovery of GDC-0917, an inhibitor of apoptosis proteins antagonist. Drug Metab Dispos. 2013 Dec;41(12):2104-13.

Other Notes

Small volumes of CUDC-427, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CUDC-427 purchase

MBS5754747 is an inhibitor targeting CUDC-427.
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