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CVT-10216 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754750

CVT-10216 is a reversible inhibitor of aldehyde dehydrogenase-2 (ALDH-2) (IC50: 29nM). CVT-10216 also has inhibitory effect of ALDH-1 (IC50: 1.3uM). CVT-10216 can reduce excessive alcohol drinking in alcohol-preferring rats and exhibit anxiolytic effects. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CVT-10216, Inhibitor
Full Product Name
CVT-10216
Product Gene Name
CVT-10216, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
465.48
Solubility
DMF: 25mg/mL (53.71mM) Need ultrasonic and warming
DMSO: 20mg/mL (42.97mM) Need ultrasonic and warming
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C24H19NO7S
SMILES
O=C(O)C1=CC=CC(COC2=CC=C3C(C(C4=CC=C(NS(=O)(C)=O)C=C4)=COC3=C2)=O)=C1
CAS Number
1005334-57-5
Target & IC50
ALDH-2: ic50 29nM
In Vitro
CVT-10216 (i.p.; 3.75 or 15mg/kg) are determined 5 h into the third withdrawal, it has the anxiolytic effect of 15mg/kg CVT-10216 in this model. However it has no significant effects on locomotor activity. CVT-10216 (i.p.; 3.75, 7.5, or 15mg/kg) shows a increase in social interaction as a dose-dependent manner, punctuated by a 2-fold increase in social interaction after 15mg/kg in Fawn-Hooded rats.

Structure of CVT-10216, inhibitor

CVT-10216 Inhibitor – Cat# MBS5754750

Product References and Citations for CVT-10216, inhibitor

Overstreet DH, et al. A selective ALDH-2 inhibitor reduces anxiety in rats.Pharmacol Biochem Behav. 2009 Dec;94(2):255-61.
Overstreet DH, et al. A selective ALDH-2 inhibitor reduces anxiety in rats.Pharmacol Biochem Behav. 2009 Dec;94(2):255-61.

Other Notes

Small volumes of CVT-10216, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CVT-10216 purchase

MBS5754750 is an inhibitor targeting CVT-10216.
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