Cyamemazine Inhibitor

Name: Cyamemazine Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754753
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754753

Cyamemazine, contains the phenothiazine chromophore, is a neuroleptic agent used as an anxiolytic. Cyamemazine is a potent 5-HT3 (Ki: 12nM), 5-HT2A (Ki: 1.5nM) and 5-HT2C (Ki: 75nM) receptors antagonist with antipsychotic activity. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Cyamemazine, Inhibitor

Full Product Name

Cyamemazine

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

323.46

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C19H21N3S

SMILES

CN(C)CC(C)CN1C2=C(C=CC(C#N)=C2)SC3=CC=CC=C31

CAS Number

3546-03-0

Target & IC50

5-HT2A Receptor: ic50 1.5nM (ki)
5-HT2C Receptor: ic50 12nM (ki)
5-HT3 Receptor: ic50 75nM (ki)

In Vitro

Cyamemazine act as an antagonist at the 5-HT3, 5-HT2C, and 5-HT2A receptors in 5-HT3-dependent contraction of isolated guinea pig ileum and bradycardic responses in rats in 5-HT2C-dependent phospholipase C stimulation in the rat brain membrane, and in 5-HT2A-dependent contraction of isolated rat aorta rings and isolated guinea pig trachea. Acute administration of low doses of Cyamemazine can reduces extracellular dopamine and metabolite concentrations in rat striatum [1].

Product Categories/Family for Cyamemazine, inhibitor

GPCR/G Protein; 5-HT Receptor; Neuroscience

Product References and Citations for Cyamemazine, inhibitor

Bourin M, et al. Preclinical and clinical pharmacology of cyamemazine: anxiolytic effects and prevention of alcohol and benzodiazepine withdrawal syndrome. CNS Drug Rev. 2004 Fall;10(3):219-29.
Bourin M, et al. Preclinical and clinical pharmacology of cyamemazine: anxiolytic effects and prevention of alcohol and benzodiazepine withdrawal syndrome. CNS Drug Rev. 2004 Fall;10(3):219-29.
Vendrell-Criado V, et al. Photobehavior of the antipsychotic drug cyamemazine in a supramolecular gel protective environment. J Photochem Photobiol B. 2020 Jan;202:111686.
Vendrell-Criado V, et al. Photobehavior of the antipsychotic drug cyamemazine in a supramolecular gel protective environment. J Photochem Photobiol B. 2020 Jan;202:111686.

Other Notes

Small volumes of Cyamemazine, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Cyamemazine purchase

MBS5754753 is an inhibitor targeting Cyamemazine.