CYM50260 Inhibitor

CYM50260 is an exquisitely agonist of sphingosine-1-phosphate 4 receptor (S1P4-R) (EC50: 45nM). CYM50260 shows no activity against S1P1-R, S1P2-R, S1P3-R and S1P5-R.

Guerrero M, et al. Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P^4-R) agonists. Bioorg Med Chem Lett. 2012 Jan 1;22(1):537-42.
Guerrero M, et al. Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P^4-R) agonists. Bioorg Med Chem Lett. 2012 Jan 1;22(1):537-42.
Onuma T, et al. Sphingosine 1-phosphate (S1P) suppresses the collagen-induced activation of human platelets via S1P4 receptor. Thromb Res. 2017 Aug;156:91-100.
Onuma T, et al. Sphingosine 1-phosphate (S1P) suppresses the collagen-induced activation of human platelets via S1P4 receptor. Thromb Res. 2017 Aug;156:91-100.

Small volumes of CYM50260, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5754757 is an inhibitor targeting CYM50260.