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CYM50308 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754758

CYM50308 is a high affinity agonist of sphingosine-1-phosphate receptor 4 (S1P4-R) (EC50: 56nM). CYM50308 has no activity at S1P1-R, S1P2-R and S1P3-R subtypes at concentrations up to 25uM and shows 37-fold more selective for S1P4-R than S1P5-R. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CYM50308, Inhibitor
Full Product Name
CYM50308
Product Gene Name
CYM50308, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
405.46
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Formula
C20H21F2N3O2S
SMILES
O=C1N(C)/C(S/C1=C\C2=C(C)N(C3=CC=C(F)C=C3F)C(C)=C2)=N/CCOC
CAS Number
1345858-76-5
Target & IC50
S1P4-R: ic50 56nM (EC50)
S1P5-R: ic50 2100nM (EC50)
In Vitro
CYM50308 shows low nanomolar S1P4-R agonist activity and exquisite selectivity over the other S1P-Rs subtypes. CYM50308 provides a valuable pharmacological tool to explore the effects of the S1P4-R signaling cascade and elucidate the molecular basis of the in vivo receptor function.

Structure of CYM50308, inhibitor

CYM50308 Inhibitor – Cat# MBS5754758

Product References and Citations for CYM50308, inhibitor

Urbano M, et al. Discovery, synthesis and SAR analysis of novel selective small molecule S1P4-R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-one chemotype. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6739-45.
Urbano M, et al. Discovery, synthesis and SAR analysis of novel selective small molecule S1P4-R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-one chemotype. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6739-45.

Other Notes

Small volumes of CYM50308, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CYM50308 purchase

MBS5754758 is an inhibitor targeting CYM50308.
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