¹H NMR Spectrum: Consistent with structure
Conclusion: The test result is consistent with sturcture.

Dapansutrile Inhibitor

Name: Dapansutrile Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754768
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754768

Dapansutrile is a potent, selective and orally active NLRP3 inflammasome inhibitor, with Anti-inflammatory and analgesic activity. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Dapansutrile, Inhibitor

Full Product Name

Dapansutrile

Preparation and Storage

Store at 0-4°C for short term (days to weeks) , or -20°C for long term (months)

Molecular Weight

133.17

Solubility

DMSO: 120mg/ml (901.1mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C4H7NO2S

CAS Number

54863-37-5

Target & IC50

NLRP3: None
NLRP3 inflammasome: None

In Vitro

Dapansutrile is a newly developed drug that is safe in humans and inhibits specifically the NLRP3 inflammasome[1].

Preparing Stock Solutions

1mg / 5mg / 10mg
1mM:
7.509 mL , 37.546 mL, 75.092 ml
5mM:
1.502mL , 7.509mL , 15.018mL
10mM:
0.751mL , 3.755mL , 7.509mL
50mM:
0.15mL , .0751mL , 1.502mL
Please select the appropriate solvent to prepare the stock solution, according to the solubility of the product in different solvents. Thestorage conditions and period of the stock solution: - 80 °C for 6 months; - 20 °C for 1 month. Please use it as soon as possible.

Product Categories/Family for Dapansutrile, inhibitor

Immunology/Inflammation; NOD; NF-kappab

Product References and Citations for Dapansutrile, inhibitor

Toldo S, et al. The NLRP3 Inflammasome Inhibitor, Dapansutrile, Reduces Infarct Size and Preserves Contractile Function After Ischemia Reperfusion Injury in the Mouse. J Cardiovasc Pharmacol. 2019 Apr;73(4):215-222.
Alba Sanchez-Fernandez, Skouras D B, Dinarello C A, et al. OLT1177 (Dapansutrile), a Selective NLRP3 Inflammasome Inhibitor, Ameliorates Experimental Autoimmune Encephalomyelitis Pathogenesis[J]. Frontiers in Immunology, 2019, 10.
Toldo S, et al. The NLRP3 Inflammasome Inhibitor, Dapansutrile, Reduces Infarct Size and Preserves Contractile Function After Ischemia Reperfusion Injury in the Mouse. J Cardiovasc Pharmacol. 2019 Apr;73(4):215-222.
Toldo S, et al. The NLRP3 Inflammasome Inhibitor, Dapansutrile, Reduces Infarct Size and Preserves Contractile Function After Ischemia Reperfusion Injury in the Mouse. J Cardiovasc Pharmacol. 2019 Apr;73(4):215-222.

Other Notes

Small volumes of Dapansutrile, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Dapansutrile purchase

MBS5754768 is an inhibitor targeting Dapansutrile.