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DFMTI Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754782

MBS5754782 is an inhibitor targeting DFMTI. DFMTI can completely block the rmGlu1 L757V glutamate response. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
DFMTI, Inhibitor
Full Product Name
DFMTI
Product Gene Name
DFMTI, inhibitor
Product Synonym Names
MK5435
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
368.38
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Formula
C20H18F2N4O
SMILES
O=C(N(C(C)C)C1)C2=C1C=C(C3=C(C)N(C4=CC=C(F)C=C4F)N=N3)C=C2
CAS Number
864864-86-8
Target & IC50
Others
In Vitro
DFMTI is efficacious in disrupting prepulse inhibition when dosed orally in rats. DFMTI exhibits a moderate decrease in human potency of approximately 3-fold when compared to rat, exemplified by DFMTI.

Structure of DFMTI, inhibitor

DFMTI Inhibitor – Cat# MBS5754782

Product References and Citations for DFMTI, inhibitor

Cho HP et al. A novel class of succinimide-derived negative allosteric modulators of metabotropic glutamate receptor subtype 1 provides insight into a disconnect in activity between the rat and human receptors. ACS Chem Neurosci. 2014 Jul 16;5(7):597-610.
Cho HP et al. A novel class of succinimide-derived negative allosteric modulators of metabotropic glutamate receptor subtype 1 provides insight into a disconnect in activity between the rat and human receptors. ACS Chem Neurosci. 2014 Jul 16;5(7):597-610.

Other Notes

Small volumes of DFMTI, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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