Dichlorophenyl-ABA Inhibitor

Solid. Powder

98.00%

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

282.12

<1mg/ml refers to the product slightly soluble or insoluble

C13H9Cl2NO2

O=C(O)C1=CC=CC=C1NC2=CC(Cl)=CC(Cl)=C2

18201-65-5

Transthyretin (TTR) amyloid fibril formation

Dichlorophenyl-ABA can prevent L55P aggregate formation in the conditioned medium. Dichlorophenyl-ABA is the best stabilizers of V30M tetramers in plasma from carriers of this mutant, and clearly inhibit aggregation in the cellular system. With regard to the ultrastructural analysis, Dichlorophenyl-ABA does not show an inhibitory effect as high as DFPB and benzoxazole. Therefore Dichlorophenyl-ABA is promising for the treatment of valine at position 30 (V30M)-associated familial amyloidotic polyneuropathy (FAP). However, it needs to undergo further stages of drug development to overcome its toxicity.