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DPC-681 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754802

DPC-681 is a potent and selective HIV protease inhibitor (IC90s: 4 to 40nM for wild-type HIV-1). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
DPC-681, Inhibitor
Full Product Name
DPC-681
Product Gene Name
DPC-681, inhibitor
Product Synonym Names
DPH-153893
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
669.85
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Formula
C35H48FN5O5S
SMILES
O=S(C1=CC(N)=CC=C1)(N(C[C@@H](O)[C@H](CC2=CC=CC=C2)NC([C@H](C(C)(C)C)NC(CNCC3=CC=CC(F)=C3)=O)=O)CC(C)C)=O
CAS Number
284661-68-3
Target & IC50
Others
In Vitro
The total body clearance (CL) of DPC 681 in dogs was high (1.8 liters/h/kg) equaling hepatic blood flow for this species (1.8 liters/h/kg). The Cmax increased ninefold between the 10- and 30-mg/kg DPC 681 dose groups. Bioavailability also increased between the 10- and 30-mg/kg dose groups (18.3 and 78.1%, respectively), after oral dosing. These data show that hepatic extraction (first-pass effect) can be saturated in the dog.

Structure of DPC-681, inhibitor

DPC-681 Inhibitor – Cat# MBS5754802

Product References and Citations for DPC-681, inhibitor

Kaltenbach RF 3rd, et al. DPC 681 and DPC 684: potent, selective inhibitors of human immunodeficiency virus protease active against clinically relevant mutant variants. Antimicrob Agents Chemother. 2001 Nov;45(11):3021-8.
Kaltenbach RF 3rd, et al. DPC 681 and DPC 684: potent, selective inhibitors of human immunodeficiency virus protease active against clinically relevant mutant variants. Antimicrob Agents Chemother. 2001 Nov;45(11):3021-8.

Other Notes

Small volumes of DPC-681, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DPC-681 purchase

MBS5754802 is an inhibitor targeting DPC-681.
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