DSM265 Inhibitor

DSM265 is a long-duration P. falciparum dihydroorotate dehydrogenase inhibitor (IC50: 8.9nM). DSM265 can also inhibit the growth of Pf3D7 parasites (EC50: 4.3nM).

Kokkonda S, et al. Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparumDihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity. J Med Chem. 2016 Jun 9;59(11):5416-31.
Kokkonda S, et al. Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparumDihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity. J Med Chem. 2016 Jun 9;59(11):5416-31.
Phillips MA, et al. A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment,of malaria. Sci Transl Med. 2015 Jul 15;7(296):296ra111.
Phillips MA, et al. A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment,of malaria. Sci Transl Med. 2015 Jul 15;7(296):296ra111.

Small volumes of DSM265, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5754807 is an inhibitor targeting DSM265.