E2012 Inhibitor – E 2012

E 2012 is a potent modulator of gamma gamma secretase without affecting Notch processing. E 2012 inhibits 3beta-hydroxysterol delta24-reductase at the final step in the cholesterol biosynthesis.

Nakano-Ito K, et al. E2012-induced cataract and its predictive biomarkers. Toxicol Sci. 2014 Jan;137(1):249-58.
Nakano-Ito K, et al. E2012-induced cataract and its predictive biomarkers. Toxicol Sci. 2014 Jan;137(1):249-58.
Portelius E, Van Broeck B, Andreasson U, Gustavsson MK, Mercken M, Zetterberg H, Borghys H, Blennow K. Acute effect on the Abeta isoform pattern in CSF in response to gamma-secretase modulator and inhibitor treatment,in dogs.J Alzheimers Dis. 2010;21(3):1005-12.
Portelius E, Van Broeck B, Andreasson U, Gustavsson MK, Mercken M, Zetterberg H, Borghys H, Blennow K. Acute effect on the Abeta isoform pattern in CSF in response to gamma-secretase modulator and inhibitor treatment,in dogs.J Alzheimers Dis. 2010;21(3):1005-12.

Small volumes of E2012, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5754811 is an inhibitor targeting E2012. Also known as E 2012.