EBI-2511 Inhibitor

Name: EBI-2511 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754813
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754813

EBI-2511 is a highly potent and orally active inhibitor of EZH2 (IC50: 6nM in Pfeffiera cell lines). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

EBI-2511, Inhibitor

Full Product Name

EBI-2511

Product Gene Name

EBI-2511, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

576.77

Solubility

DMSO: 5mg/mL (8.67mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C34H48N4O4

SMILES

CCC1=C(C(NCC2=C(C)C=C(C)NC2=O)=O)C(C=C(C3CCN(C(C)C)CC3)O4)=C4C=C1N(C5CCOCC5)CC

CAS Number

2098546-05-3

Target & IC50

EZH2: ic50 6nM

In Vitro

EBI-2511 shows a dose-dependent inhibition on the tumor growth, resulting in 28% (10mg/kg), 83% (30mg/kg), and 97% (100mg/kg) reduction in tumor size. There are no significant changes in body weights of all treatment, groups are observed. At the same dosage level, EBI-2511 displays a superior anti-tumor efficacy to EPZ-6438 (P<0.01).

Product Categories/Family for EBI-2511, inhibitor

Chromatin/Epigenetic; Histone Methyltransferase

Product References and Citations for EBI-2511, inhibitor

Lu B, et al. Discovery of EBI-2511: A Highly Potent and Orally Active EZH2 Inhibitor for the treatment,of Non-Hodgkin's Lymphoma. ACS Med Chem Lett. 2018 Jan 29;9(2):98-102.
Lu B, et al. Discovery of EBI-2511: A Highly Potent and Orally Active EZH2 Inhibitor for the treatment,of Non-Hodgkin's Lymphoma. ACS Med Chem Lett. 2018 Jan 29;9(2):98-102.

Other Notes

Small volumes of EBI-2511, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EBI-2511 purchase

MBS5754813 is an inhibitor targeting EBI-2511.