Ebrotidine Inhibitor

Ebrotidine is a competitive H2-receptor antagonist (Ki: 127.5nM). It has a potent antisecretory activity and evidenced gastroprotection.

Agut J, Sanchez JC, Sacristan A, Action of ebrotidine, ranitidine and cimetidine on the specific binding to histamine H- and H2-receptors. Arzneimittelforschung. 1997 Apr;47(4A):447-9.
Agut J, Sanchez JC, Sacristan A, Action of ebrotidine, ranitidine and cimetidine on the specific binding to histamine H- and H2-receptors. Arzneimittelforschung. 1997 Apr;47(4A):447-9.
Palop D, Agut J, Marquez M, histamine H-receptor antagonist action of ebrotidine. Effects on gastric acid secretion, gastrin levels and NSAID-induced gastrotoxicity in the rat. Arzneimittelforschung. 1997 Apr;47(4A):439-46.
Palop D, Agut J, Marquez M, histamine H-receptor antagonist action of ebrotidine. Effects on gastric acid secretion, gastrin levels and NSAID-induced gastrotoxicity in the rat. Arzneimittelforschung. 1997 Apr;47(4A):439-46.
Konturek SJ, Kwiecien N, Sito E, Effects of ebrotidine on aspirin-induced gastric mucosal damage and blood flow in humans. Scand J Gastroenterol. 1993 Dec;28(12):1047-50.
Konturek SJ, Kwiecien N, Sito E, Effects of ebrotidine on aspirin-induced gastric mucosal damage and blood flow in humans. Scand J Gastroenterol. 1993 Dec;28(12):1047-50.
Piotrowski J, Yamaki K, Morita M, Ebrotidine--a new H2-receptor antagonist with mucosal strengthening activity. Biochem Int. 1992 Mar;26(4):659-67.
Piotrowski J, Yamaki K, Morita M, Ebrotidine--a new H2-receptor antagonist with mucosal strengthening activity. Biochem Int. 1992 Mar;26(4):659-67.

Small volumes of Ebrotidine, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5754814 is an inhibitor targeting Ebrotidine.