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MAK683 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754818

MAK683 is an inhibitor of embryonic ectoderm development (EED) (IC50s: 59, 89, 26nM in EED Alphascreen binding, LC-MS and ELISA assay). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MAK683, Inhibitor
Full Product Name
MAK683
Product Gene Name
MAK683, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
376.39
Solubility
DMSO: 50mg/mL (132.84mM) Need ultrasonic
H2O: <0.1mg/mL (insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C20H17FN6O
SMILES
Cc1ncccc1-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
CAS Number
1951408-58-4
Target & IC50
EED Alphascreen: ic50 59nM
LC-MS: ic50 89nM
ELISA: ic50 26nM
In Vitro
After treatment,14 days, MAK683 has antiproliferative activities in B cell lymphoma cell KARPAS422 (IC50: 30nM) [1].

Structure of MAK683, inhibitor

MAK683 Inhibitor – Cat# MBS5754818

Product References and Citations for MAK683, inhibitor

Chan, Ho Man, et al. TRIAZOLOPYRIMIDINE COMPOUNDS AND USES THEREOF. US20160176882 A1.
Chan, Ho Man, et al. TRIAZOLOPYRIMIDINE COMPOUNDS AND USES THEREOF. US20160176882 A1.
Huang D, et al. Binding Modes of Small-Molecule Inhibitors to the EED Pocket of PRCChemphyschem. 2020 Feb 4;21(3):263-271.
Huang D, et al. Binding Modes of Small-Molecule Inhibitors to the EED Pocket of PRC2. Chemphyschem. 2020 Feb 4;21(3):263-271.

Other Notes

Small volumes of MAK683, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MAK683 purchase

MBS5754818 is an inhibitor targeting MAK683.
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