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Enarodustat Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754830

Enarodustat is an orally active factor inhibitor of prolyl hydroxylase (EC50: 0.22uM) and has the potential for renal anemia treatment. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Enarodustat, Inhibitor
Full Product Name
Enarodustat
Product Synonym Names
JTZ-951
Form/Format
Solid. Powder
Purity/Purification
99.61%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
340.33
Solubility
DMSO: 83.33mg/mL (244.85mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C17H16N4O4
SMILES
OC(=O)CNC(=O)c1c(O)cc(CCc2ccccc2)n2ncnc12
CAS Number
1262132-81-9
Target & IC50
factor prolyl hydroxylase: ic50 0.22uM (EC50)
In Vitro
Enarodustat (1 and 3mg/kg, p.o., in rats) treatment,increases hemoglobin levels in a dose-dependent manner.

Structure of Enarodustat, inhibitor

Enarodustat Inhibitor – Cat# MBS5754830

Product References and Citations for Enarodustat, inhibitor

Ogoshi Y, et al. Discovery of JTZ-951: A HIF Prolyl Hydroxylase Inhibitor for the treatment,of Renal Anemia. ACS Med Chem Lett. 2017 Nov 20;8(12):1320-1325.
Ogoshi Y, et al. Discovery of JTZ-951: A HIF Prolyl Hydroxylase Inhibitor for the treatment,of Renal Anemia. ACS Med Chem Lett. 2017 Nov 20;8(12):1320-1325.

Other Notes

Small volumes of Enarodustat, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Enarodustat purchase

MBS5754830 is an inhibitor targeting Enarodustat.
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