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GLPG0974 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754901

MBS5754901 is an inhibitor targeting GLPG0974. GLPG0974 is an antagonist of free fatty acid receptor-2 (IC50: 9nM). More details

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Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GLPG0974, Inhibitor
Full Product Name
GLPG0974
Product Gene Name
GLPG0974, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
485
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Formula
C25H25ClN2O4S
SMILES
O=C(O)CCCN(C([C@]1(C)N(C(C2=CSC3=CC=CC=C32)=O)CC1)=O)CC4=CC=CC(Cl)=C4
CAS Number
1391076-61-1
Target & IC50
GPR43: ic50 9nM
In Vitro
In humans, the extended half-life observed following the enhancement of the oral dose is consistent with the project objective to obtain long target coverage. After oral dosing at 5 and 30mg/kg, GLPG0974 displays excellent pharmacokinetic properties in rats with a bioavailability of 47% and a linear increase of plasma exposure.

Product Categories/Family for GLPG0974, inhibitor

Endocrinology/Hormones; GPR; GPCR/G Protein

Structure of GLPG0974, inhibitor

GLPG0974 Inhibitor – Cat# MBS5754901

Product References and Citations for GLPG0974, inhibitor

Pizzonero M, et al. Discovery and optimization of an azetidine chemical series as a free fatty acid receptor 2 (FFA2) antagonist: from hit to clinic. J Med Chem. 2014 Dec 11;57(23):10044-57.
Pizzonero M, et al. Discovery and optimization of an azetidine chemical series as a free fatty acid receptor 2 (FFA2) antagonist: from hit to clinic. J Med Chem. 2014 Dec 11;57(23):10044-57.

Other Notes

Small volumes of GLPG0974, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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