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GNE-6468 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754911

GNE-6468 is a potent and selective agonist of RORgamma(RORc) (EC50: 13nM for HEK-293 cell). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GNE-6468, Inhibitor
Full Product Name
GNE-6468
Product Gene Name
GNE-6468, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
433.84
Solubility
DMSO: 5mg/mL (11.52mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C23H16ClN3O4
SMILES
OC1=CC(C2=C3N(C(C(C4=C(C5CC5)C=CC=C4Cl)=O)=N2)C=CC=N3)=CC=C1C(O)=O
CAS Number
1677668-27-7
Target & IC50
Others

Structure of GNE-6468, inhibitor

GNE-6468 Inhibitor – Cat# MBS5754911

Product References and Citations for GNE-6468, inhibitor

Fauber BP, et al. Discovery of imidazo[1,5-a]pyridines and -pyrimidines as potent and selective RORc inverse agonists. Bioorg Med Chem Lett. 2015 Aug 1;25(15):2907-12.
Fauber BP, et al. Discovery of imidazo[1,5-a]pyridines and -pyrimidines as potent and selective RORc inverse agonists. Bioorg Med Chem Lett. 2015 Aug 1;25(15):2907-12.

Other Notes

Small volumes of GNE-6468, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GNE-6468 purchase

MBS5754911 is an inhibitor targeting GNE-6468.
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