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GNE0723 Inhibitor – GNE 0723

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754913

GNE 0723 is annMDAR brain permeable positive allosteric modulator (EC50: 21nM for GluN2A; 7.4 and 6.2uM for GluN2C and GluN2D, respectively). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GNE 0723 (GNE0723), Inhibitor
Full Product Name
GNE 0723
Product Gene Name
GNE0723, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
467.78
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Formula
C16H8ClF6N5OS
SMILES
N#C[C@H]1[C@H](C2=C(C(F)(F)F)SC3=NC(CN4N=C(C(F)(F)F)C=C4Cl)=CC(N32)=O)C1
CAS Number
1883518-31-7
Target & IC50
GluN2A: ic50 21nM (EC50)
GluN2C: ic50 7.4uM (EC50)
GluN2D: ic50 6.2uM (EC50)

Structure of GNE0723, inhibitor

GNE0723 Inhibitor – Cat# MBS5754913

Product References and Citations for GNE0723, inhibitor

Villemure E, et al. GluN2A-Selective Pyridopyrimidinone Series of nMDAR Positive Allosteric Modulators with an Improved in Vivo Profile. ACS Med Chem Lett. 2016 Oct 31;8(1):84-89.
Villemure E, et al. GluN2A-Selective Pyridopyrimidinone Series of nMDAR Positive Allosteric Modulators with an Improved in Vivo Profile. ACS Med Chem Lett. 2016 Oct 31;8(1):84-89.

Other Notes

Small volumes of GNE0723, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GNE0723 purchase

MBS5754913 is an inhibitor targeting GNE0723. Also known as GNE 0723.
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